Spike is an English Bull Terrier with a keen comedic eye for human foibles. He rockets to TV and internet fame after appearing on The Tonight Show with Jimmy Fallon, along with his master, Bud, who hosts a local morning show in High Point, North Carolina. Spike and Bud soon hit the fast track to bigger stardom when Bud signs on for a talk show in New York City.

They embark on an endless stream of mind-boggling adventures that include the world's first topless theme park, a rabbi promoting Christmas shows, and a yogi who discovers Spike's comical talent for teaching Transcendental Meditation.

Spike's pop culture fame and the A-list crowd he mingles with in Manhattan exact a potentially fatal price. Dangerous forces enact a scheme to snatch the famous wonder dog and plunge him into an international dog fighting ring.

Spike calls to mind the cultural icon Rocky Balboa as he goes into battle armed with humor and guile as well as the ancient, but never tested, skills of his breed. Will they be enough to enable him to survive?