HighBridge Audio

Skip to Main Content »

Category Navigation:

Search Site


Nonfiction: Science
Unabridged   7 hour(s)
Publication date: 08/06/2019


A Doctor, a Drug, and a Breakthrough

Available from major retailers or BUY FROM AMAZON
Audio CD ISBN:9781684572885
Digital Download ISBN:9781684572892


The remarkable untold story of a miracle drug, the forgotten pioneer who discovered it, and the fight to bring lithium to the masses.

Be the first to review this product
Email to a Friend

Product Description

From insulin comas and lobotomy to incarceration to exile, Walter Brown chronicles the troubling history of the diagnosis and (often ineffective) treatment of bipolar disorder through the centuries, before the publication of a groundbreaking research paper in 1949. Cade's "Lithium Salts in the Treatment of Psychotic Excitement" described, for the first time, lithium's astonishing efficacy at both treating and preventing the recurrence of manic-depressive episodes, and would eventually transform the lives of patients, pharmaceutical researchers, and practicing physicians worldwide. And yet, as Brown shows, it would be decades before lithium would overcome widespread stigmatization as a dangerous substance, and the resistance from the pharmaceutical industry, which had little incentive to promote a naturally occurring drug that could not be patented.

Brown also provides a vivid portrait of the story's unlikely hero, John Cade, a devoted naturalist who, unlike many modern medical researchers, did not benefit from prestigious research training or big funding sources. In this revelatory biography of a drug and the man who fought for its discovery, Brown crafts a captivating picture of modern medical history—revealing just how close we came to passing over this extraordinary cure.


“Blending medical history, psychopharmacology, and biography, psychiatrist Brown tells a tantalizing tale of a remarkably effective but underused medication.... A fascinating and valuable history.”—Tony Miksanek, Booklist

“In this comprehensive history, Brown, a psychiatrist and professor at Brown University, meticulously traces the research, theories, and people behind the discovery of lithium as a successful bipolar disorder treatment.... [Lithium] makes for a worthy chronicle of a significant topic.” —Publishers Weekly

Author Bio

Walter A. Brown has been a practicing psychiatrist and professor at Brown University for more than forty years. He has contributed to publications such as Scientific American, Scientific American Mind, and Psychology Today. He lives in Tiverton, Rhode Island.